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張俊兵

張俊兵

博士
細(xì)胞代謝與疾病干預(yù)研究組組長(zhǎng)

郵箱: junbingzhang@sinh.ac.cn

電話: +86-21-

所屬部門: 中國(guó)科學(xué)院營(yíng)養(yǎng)代謝與食品安全重點(diǎn)實(shí)驗(yàn)室

個(gè)人簡(jiǎn)歷

2025.02－至　?今：中國(guó)科學(xué)院上海營(yíng)養(yǎng)與健康研究所 研究員
2024.05－2025.01：美國(guó)哈佛大學(xué)醫(yī)學(xué)院 講師
2019.06－2024.04：美國(guó)哈佛大學(xué)醫(yī)學(xué)院附屬麻省總醫(yī)院 博士后
2013.09－2019.05：北京生命科學(xué)研究所 博士
2010.09－2013.06：山東大學(xué)生命科學(xué)學(xué)院 碩士
2006.09－2010.06：山東大學(xué)生命科學(xué)學(xué)院 學(xué)士

研究方向

細(xì)胞代謝與翻譯后修飾

研究?jī)?nèi)容

代謝穩(wěn)態(tài)的維持對(duì)于所有生命體來(lái)說(shuō)是必需的，代謝異常會(huì)導(dǎo)致多種人類疾病的發(fā)生，如衰老、神經(jīng)退行性疾病、糖尿病和癌癥等。本課題組通過(guò)結(jié)合一系列前沿高通量技術(shù)，如CRISPR遺傳篩選、堿基編輯篩選、代謝組學(xué)和定量化學(xué)蛋白質(zhì)組學(xué)等，來(lái)深入探索細(xì)胞代謝異常與癌癥、衰老相關(guān)疾病之間的關(guān)系。我們的長(zhǎng)期研究目標(biāo)是鑒定癌癥及衰老相關(guān)疾病中的可成藥靶點(diǎn)與代謝相關(guān)的致命弱點(diǎn)。
研究課題：
1.亞細(xì)胞水平活性氧（ROS）的感應(yīng)及調(diào)控
2.利用遺傳蛋白質(zhì)組學(xué)方法鑒定代謝物的感應(yīng)機(jī)制
3.基于半胱氨酸蛋白質(zhì)組學(xué)的藥物發(fā)現(xiàn)

代表論著（#第一作者，*通訊作者）

  1. Junbing Zhang#*, Md Yousuf Ali#, Harrison Byron Chong#, Pei-Chieh Tien, James Woods, Carolina Noble, Tristan Vornb?umen, Zehra Ordulu, Anthony P Possemato, Stefan Harry, Jay Miguel Fonticella, Lina Fellah, Drew Harrison, Maolin Ge, Neha Khandelwal, Yingfei Huang, Ma?va Chauvin, Anica Tamara Bischof, Grace Marie Hambelton, Magdy Farag Gohar, Siwen Zhang, MinGyu Choi, Sara Bouberhan, Esther Oliva, Mari Mino-Kenudson, Natalya N Pavlova, Michael Lawrence, Justin F Gainor, Sean A Beausoleil, Nabeel Bardeesy, Raul Mostoslavsky, David Pépin, Christopher J Ott, Brian Liau, Liron Bar-Peled*. Oxidation of retromer complex controls mitochondrial translation. Nature 2025 May;641(8064):1048-1058.
    ● Research watch. ROS Sensing Regulates Mitochondrial Translation and Chemotherapy Response. Cancer discovery 2025. https://doi.org/10.1158/2159-8290.CD-RW2025-040.
  2. Junbing Zhang*, Liron Bar-Peled*. Chemical Biology Approaches to Uncovering Nuclear ROS Control. Current Opinion in Chemical Biology 2023 Jun 21;76:102352.
  3. Junbing Zhang*, Claire M. Simpson, Jacqueline Berner, Harrison B. Chong, Jiafeng Fang, Zehra Ordulu, Tommy Weiss-Sadan, Anthony P. Possemato, Stefan Harry, Mariko Takahashi, Tzu-yi Yang, Marianne Richter, Himani Patel, Abby E. Smith, Alexander D. Carlin, Adriaan F. Hubertus de Groot, Konstantin Wolf, Lei Shi, Ting-Yu Wei, Benedikt R. Dürr, Nicholas J. Chen, Tristan Vornb?umen, Nina O. Wichmann, Mohammed S. Mahamdeh, Venkatesh Pooladanda, Yusuke Matoba, Shaan Kumar, Eugene Kim, Sara Bouberhan, Esther Oliva, Bo R. Rueda, Roy J. Soberman, Nabeel Bardeesy, Brian B. Liau, Michael Lawrence, Matt P. Stokes, Sean A. Beausoleil, Liron Bar-Peled*. Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway. Cell 2023;186(11):2361-2379.
    ● Highlight. A ROS-mediated resistance pathway to anticancer drugs. Nature Reviews Drug Discovery 22, 534 (2023). https://doi.org/10.1038/d41573-023-00094-w.
    ● Highlight. How CHKing ROS signaling preserves genomic integrity. Cell Res (2023). https://doi.org/10.1038/s41422-023-00840-0.
    ● Highlight. Cys-regulation: oxidized CHK1 controls cross-compartment circuit of chemoresistance. Trends in Cancer 2023, Pages 700-702. https://www.sciencedirect.com/science/article/abs/pii/S2405803323001322.
    ● Research watch. DNA Damage Response and Mitochondrial Translation Mediate ROS Response. Cancer discovery 2023, p.OF1-OF1. https://doi.org/10.1158/2159-8290.CDRW2023-085.
  4. Junbing Zhang, Jinchao Liu, Anne Norris, Barth D Grant, Xiaochen Wang, Wang X. A novel requirement for ubiquitin conjugating enzyme UBC-13 in retrograde recycling of MIG-14/Wntless and Wnt signaling. Mol Biol Cell 2018;29(17):2098-2112.
  5. Guijun Shang#, Deyu Zhu#, Ning Li#, Junbing Zhang#, Chunyuan Zhu, Defen Lu, Cuilan Liu, Qian Yu, Yanyu Zhao, Sujuan Xu, Lichuan Gu. Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP. Nat Struct Mol Biol 2012 Jun 24;19(7):725-727.
  6. Junbing Zhang, Liron Bar-Peled. How Sweet It Is: Small-Molecule Inhibitors of mTORC1 Glucose Sensing. Cell Chemical Biology 2019;26(9):1195-1196.
  7. Letao Li, Xilu Liu, Shanshan Yang, Meijiao Li, Yanwei Wu, Siqi Hu, Wenjuan Wang, Amin Jiang, Qianqian Zhang, Junbing Zhang, Xiaoli Ma, Junyan Hu, Qiaohong Zhao, Yubing Liu, Dong Li, Junjie Hu, Chonglin Yang, Wei Feng, Xiaochen Wang. The HEAT repeat protein HPO-27 is a lysosome fission factor. Nature 2024 Apr;628(8008):630-638.
  8. Rui Miao, Cong Jiang, Winston Y Chang, Haiwei Zhang, Jinsu An, Felicia Ho, Pengcheng Chen, Han Zhang, Caroline Junqueira, Dulguun Amgalan, Felix G Liang, Junbing Zhang, Charles L Evavold, Iva Hafner-Bratkovi?, Zhibin Zhang, Pietro Fontana, Shiyu Xia, Markus Waldeck Weiermair, Youdong Pan, Thomas Michel, Liron Bar-Peled, Hao Wu, Jonathan C Kagan, Richard N Kitsis, Peng Zhang, Xing Liu, Judy Lieberman. Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis. Immunity 2023 Nov 14;56(11):2523-2541.
  9. Tommy Weiss-Sadan, Maolin Ge, Makiko Hayashi, Magdy Gohar, Cong-Hui Yao, Adriaan de Groot, Stefan Harry, Alexander Carlin, Hannah Fischer, Lei Shi, Ting-Yu Wei, Charles H Adelmann, Konstantin Wolf, Tristan Vornb?umen, Benedikt R Dürr, Mariko Takahashi, Marianne Richter, Junbing Zhang, Tzu-Yi Yang, Vindhya Vijay, David E Fisher, Aaron N Hata, Marcia C Haigis, Raul Mostoslavsky, Nabeel Bardeesy, Thales Papagiannakopoulos, Liron Bar-Peled. NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer. Cell Metab 2023 Apr 4;35(4):722.
  10. Noritaka Tanaka, Jessica J Lin, Chendi Li, Meagan B Ryan, Junbing Zhang, Lesli A Kiedrowski, Alexa G Michel, Mohammed U Syed, Katerina A Fella, Mustafa Sakhi, Islam Baiev, Dejan Juric, Justin F Gainor, Samuel J Klempner, Jochen K Lennerz, Giulia Siravegna, Liron Bar-Peled, Aaron N Hata, Rebecca S Heist, Ryan B Corcoran. Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation. Cancer Discov 2021;11(8):1913-1922.
  11. Guijun Shang, Xiuhua Liu, Defen Lu, Junbing Zhang, Ning Li, Chunyuan Zhu, Shiheng Liu, Qian Yu, Yanyu Zhao, Heqiao Zhang, Junqiang Hu, Huaixing Cang, Sujuan Xu, Lichuan Gu. Structural insight into how Pseudomonas aeruginosa peptidoglycanhydrolase Tse1 and its immunity protein Tsi1 function. Biochem J 2012 Dec 1;448(2):201-211.
  12. Duohong Sheng, Jiandong Jao, Mingfeng Li, Peng Xu, Junbing Zhang. RecX is involved in the switch between DNA damage response and normal metabolism in D. radiodurans. J Biochem 2009 Sep;146(3):337-342.


招聘信息：

實(shí)驗(yàn)室常年歡迎博士后及有志于科研的人才加入，有意者請(qǐng)將個(gè)人簡(jiǎn)歷、研究興趣及推薦人信息發(fā)送到郵箱（junbingzhang@sinh.ac.cn）。